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. 2011 Jun 20;13(3):R95. doi: 10.1186/ar3370

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Copyright ©2011 Appel et al.; licensee BioMed Central Ltd

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction.

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Peripheral and synovial CD4⁺IL-17⁺T cell levels in spondyloarthritis, rheumatoid arthritis and controls. Analysis of (a) peripheral blood (PB) and (b) synovial fluid (SF) CD4⁺IL-17⁺T cells in spondyloarthritis (SpA) patients (PB n = 30, SF n = 11), rheumatoid arthritis (RA) patients (PB n = 14, SF n = 7), osteoarthritis (OA) patients (PB n = 10) and healthy controls (C) (PB n = 12). Similar levels of PB and SF CD4⁺IL-17⁺T cells after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin or Staphylococcus aureus Enterotoxin B (SEB) antibodies are seen when SpA patients are compared to RA patients. The frequency of PB CD4⁺IL-17⁺T cells was only significantly lower in SpA patients than in controls when stimulated with SEB antibodies (P < 0.05).