Table 2.
Incidence of disease recurrence and deaths according to the detection of CK-19 mRNA-positive circulating tumor cells
| CK-19 mRNA | No of patients | Relapses | Deaths | ||||
|---|---|---|---|---|---|---|---|
| Yes N (%) |
No N (%) |
Fisher's Exact test, P | Dead N (%) |
Alive N (%) |
Fisher's Exact test, P | ||
| Persistently Positive | 99 | 36 (36.4) | 63 (63.6) | P < 0.001 | 24 (24.2) | 75 (75.8) | P = 0.001 |
| Persistently Negative | 80 | 9 (11.2) | 71 (88.8) | 5(6.3) | 75 (93.8) | ||
| Positive Turn to negative | 64 | 5 (7.8) | 59 (92.2) |
P < 0.001 versus persistently positive |
3 (4.7) | 61 (95.3) |
P = 0.001 versus persistently positive |
| Negative Turn to positive | 69 | 13 (18.8) | 56 (81.2) |
P = 0.016 versus persistently positive |
9 (13.0) | 60 (87.0) |
P = 0.079 versus persistently positive |
While also,
P = .248 for relapse of turn to positive versus persistently negative
P = .172 for deaths of turn to positive versus persistently negative
CK-19, cytokeratine-19.