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14-3-3ζ status impacts the activation of key signaling proteins. Phosphorylation of human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR), AKT/Protein kinase B (AKT/PKB), and mitogen activated protein kinase (MAPK) was investigated by western blot in tamoxifen-resistant cells following siRNA knockdown or overexpression of 14-3-3ζ and treatment with 1 μM tamoxifen (Tam).
