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Adjusted estimated survival curves by covariates of APACHE II score and sex in final multivariate Cox regression models. The solid line represents patients in the rhTM group, and the dotted line represents patients in the control group. Treatment with rhTM was associated with a significantly higher rate of survival (P = 0.027 by stratified Cox regression analysis). APACHE II, Acute Physiology and Chronic Health Evaluation II; rhTM, recombinant human soluble thrombomodulin.
