Table 3.
Discriminative power of mean arterial pressure to predict acute kidney insufficiency at H72
| AUC for MAP averaged over H6 to H24 | Best MAP threshold (mmHg) |
Sensitivity | Specificity | AUC for MAP averaged over H12 to H24 | Best MAP threshold (mmHg) |
Sensitivity | Specificity | |
|---|---|---|---|---|---|---|---|---|
| Patients with no AKI at H6 (n = 116) | 0.53 (0.43 to 0.62) |
- | - | - | 0.50 (0.41 to 0.60) |
- | - | - |
| Patients with AKI at H6 (n = 101) |
0.74* (0.66 to 0.83) |
69 | 0.53 (0.38 to 0.69) |
0.91 (0.81 to 0.97) |
0.75** (0.66 to 0.84) |
70 | 0.59 (0.42 to 0.74) |
0.86 (0.75 to 0.94) |
| Patients with non septic shock (n = 90) | 0.60 (0.49 to 0.11) |
- | - | - | 0.59 (0.48 to 0.59) |
- | - | - |
| Septic shock patients (n = 127) |
0.72 (0.63 to 0.79) |
72 | 0.56 (0.38 to 0.72) |
0.84 (0.74 to 0.91) |
0.72 (0.63 to 0.80) |
72 | 0.61 (0.42 to 0.77) |
0.84 (0.74 to 0.91) |
| Non septic shock patients only: | ||||||||
| Patients with no AKI at H6 (n = 52) | 0.57 (0.42 to 0.71) |
- | - | - | 0.47 (0.33 to 0.61) |
- | - | - |
| Patients with AKI at H6 (n = 38) |
0.59 (0.42 to 0.74) |
- | - | - | 0.61 (0.44 to 0.77) |
- | - | - |
| Septic shock patients only: | ||||||||
| Patients with no AKI at H6 (n = 63) | 0.52 (0.39 to 0.64) |
- | - | - | 0.53 (0.40 to 0.66) |
- | - | - |
| Patients with AKI at H6 (n = 64) |
0.83†,†† (0.72 to 0.92) |
72 | 0.72 (0.51 to 0.88) |
0.87 (0.72 to 0.96) |
0.84‡,‡‡ (0.72 to 0.92) |
72 | 0.78 (0.56 to 0.93) |
0.89 (0.72-0.96) |
*: P = 0.011 versus patients with no AKI at H6; **: P = 0.003 versus patients with no AKI at H6; †: P = 0.0037 versus septic shock patients with no AKI at H6;
††: P = 0.02 versus non septic shock patients with AKI at H6; ‡: P = 0.0065 versus septic shock patients with no AKI at H6; ‡‡: P = 0.036 versus non septic shock patients with AKI at H6
AKI: Acute kidney insufficiency; AUC: Area under the receiver operating characteristics curve; MAP: Mean arterial pressure.