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Chronic social defeat stress regulates levels of IKK. A, Social defeat increases total levels of IKK protein. B, Levels of IKK correlate with SI ratio. C, D, Levels of IκB (C) and phosphorylated IκB (p-IκB; D), downstream targets of IKK, are significantly increased after chronic social defeat stress. All data are expressed as mean ± SEM optical density percentage control. *p < 0.05, t p < 0.07, one-way ANOVA, n = 8–10 mice per group.
