Figure 1.
Potential antiobesity molecular targets in metabolically relevant hypothalamic neurons. POMC and AgRP/NPY neurons are critical for coordinated energy balance. In green are depicted molecules that positively regulate, whereas in red are the ones that negatively affect metabolic sensing in these neurons. Pharmacologically mediated activation of SIRT1 and SHP2 in POMC neurons combined with the inhibition of SOCS3 and PTP1B in POMC and NF-κB/IKKβ in AgRP neurons may be an effective approach to reverse energy imbalance brought about by hypercaloric feeding.