Figure 7.

Anti-cancer effect of OGX-427 on MiaPaCa-2 tumor growth and gemcitabine sensitivity in vivo. (a) and (b) MiaPaCa-2 tumor volume measurement (length × width × depth × 0.5236) in 40 nude randomly selected for treatment with OGX-427 or ASO control. When MiaPaCa-2 tumors reached 300–500 mm³, OGX-427 or ASO control were injected i.p. for 5 weeks for OGX-427 (a and b) (see Materials and Methods section). Points represent mean tumor volume in each experimental group containing 10 mice; Error bars represent S.E. Statistical analysis used t test; ^*P≤0.05, ^**P≤0.01. (c) IHC staining of MiaPaCa-2 tumor xenografts. Tumors were resected and processed for histological analysis as previously described in Materials and Methods sections. Tissue sections were stained with antibodies to ki67 and cleaved caspase-3