Table 1.
Gene transcripts | WT (−) | WT (pIC) | Irf2−/−(−) | Irf2−/− (pIC) |
Prss1 (T16, Trypsin1) | 11,161 | 13,863 | 10,388 | 13,788 |
Prss2 (T20, Trypsin 2) | 16,041 | 15,661 | 15,857 | 15,494 |
Prss3 (T11, Trypsin 3) | 1,155 | 1,131 | 3,059 ↑ | 2,395 ↑ |
Trypsinogen5 (T4, 1810009J06Rik) | 70 | 57 | 13,514 ↑ | 14,287 ↑ |
Chymotrypsin C (Ctrc) | 545 | 368 | 87 ↓ | 119 ↓ |
Chymotrypsinogen B 1 (Ctrb1) | 19,417 | 18,772 | 20,457 | 19,919 |
Amylase2-2, pancreatic (Amy2b) | 19,101 | 18,488 | 17,092 | 18,261 |
Calcium-sensing receptor (Casr) | 37 | 37 | 30 | 26 |
Cystic fibrosis membrane conductance regulator (Cftr) | 7 | 6 | 11 | 8 |
Cathepsin B (Ctsb) | 349 | 443 | 848 ↑ | 794 ↑ |
Serine protease inhibitor, Kazal-type 3 (Spink3) | 4,716 | 3,957 | 7,497 | 7,774 |
Inter-α-trypsin inhibitor, heavy chain 4 (Itih4) | 375 | 212 | 78 ↓ | 71 ↓ |
Galanin (Gal) | 879 | 1,057 | 213 ↓ | 71 ↓ |
The levels of gene expression in the pancreas are shown in Affymetrix units. The trypsinogen5 data are Point 1 in Fig. 2.