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Heterosexual transmission across a mucosal barrier. (A) GT-derived virus population at the time of sampling contains a large subpopulation of virus (red virions), as well as numerous other variants. In this study, only one of these variants, distinct from the large variant population, successfully crosses the mucosal epidermis barrier of the genitals (B) to generate an infection capable of spreading to all lymphoid tissues of the recipient (C).
