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. 2011 Oct 27;108(46):E1164–E1173. doi: 10.1073/pnas.1112304108

Fig. 6.

Fig. 6.

Induced expression of connexin 30 in the labyrinth of SynB−/− mice. (A) Real-time quantitative RT-PCR analysis of connexin 30 and connexin 26 gene expression in the placenta from WT (+/+) and mutant (−/−) embryos at different embryonic days (E). Values (transcript levels expressed as percent of maximum, after normalization with 18S RNA) are means ± SEM of three to nine living embryos. A significant induction of connexin 30 expression is observed in SynB−/− placenta, whereas the expression of connexin 26 is not modified. (B) Immunohistochemical staining for Connexin 30 on cryostat sections of WT (SynB+/+) or SynB−/− placenta. The labyrinth (lb) region shows positive cells in SynB−/− placenta (Center) but not in WT placenta (Left). (Right) Enlarged view showing Connexin 30-positive signals at the interhemal layer between maternal blood lacunae (ml) and a fetal blood vessel (fv), with the labeling being closer to fetal blood spaces than to maternal blood spaces. frbc, fetal red blood cells. (Scale bar: 25 μm.)