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. 2011 Nov 7;108(46):18784–18789. doi: 10.1073/pnas.1116152108

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Fig. 2. — Inflammation modulates lymphatic contraction through iNOS. (A) Representative lymphatic contraction curves for WT, eNOS^−/−, and iNOS^−/− mice during inflammation. Only PLVs in iNOS^−/− mice maintain strong contractions. (B) Lymphatic contraction analyses at day 4 after OX painting. , C57BL/6, n = 14; , iNOS^−/−, n = 15; , eNOS^−/−, n = 9. (C) Immunohistochemical staining shows a large cell infiltrate of iNOS⁺ cells into the s.c. area of inflamed skin (OXd4). (D) Mice implanted with iNOS^−/− macrophages maintain strong lymphatic contractions compared with control. , WT macrophage, n = 8; , iNOS^−/− macrophage, n = 8. *P < 0.05. P values are listed in Table S1. Error bars show SEM.

Inline graphic — Inflammation modulates lymphatic contraction through iNOS. (A) Representative lymphatic contraction curves for WT, eNOS^−/−, and iNOS^−/− mice during inflammation. Only PLVs in iNOS^−/− mice maintain strong contractions. (B) Lymphatic contraction analyses at day 4 after OX painting. , C57BL/6, n = 14; , iNOS^−/−, n = 15; , eNOS^−/−, n = 9. (C) Immunohistochemical staining shows a large cell infiltrate of iNOS⁺ cells into the s.c. area of inflamed skin (OXd4). (D) Mice implanted with iNOS^−/− macrophages maintain strong lymphatic contractions compared with control. , WT macrophage, n = 8; , iNOS^−/− macrophage, n = 8. *P < 0.05. P values are listed in Table S1. Error bars show SEM.