Table 2.
Organ weight of SCD and SCD:TgTR2/TR4 mice
| Genotype |
||||||||
| Mouse | Hba | Hbb | TgTR2/TR4 | No. | Age (mo) | Spleen (% body weight) | Liver (% body weight) | Kidneys (% body weight) |
| Wild-type (C57BL/6) | +/+ | +/+ | – | 6 | 2.5 | 0.36 ± 0.16 | 5.0 ± 0.79 | 1.6 ± 0.23 |
| Heterozygous SCD | hα/hα | hγβS/+ | – | 10 | 2–3 | 1.2 ± 0.44 | 7.0 ± 1.31 | 2.1 ± 0.82 |
| SCD | hα/hα | hγβS/hγβS | – | 8 | 2–3 | 4.8 ± 1.34 | 8.8 ± 1.18 | 2.2 ± 0.33 |
| SCD:TgTR2/TR4 | hα/hα | hγβS/hγβS | + | 6 | 2–3 | 3.7 ± 0.46 | 7.6 ± 0.69 | 2.2 ± 0.35 |
| P value | <0.05 | <0.05 | 0.42 | |||||
Numbers following ± in the Spleen, Liver, and Kidney columns refer to SDs among the stated numbers of mice. P values refer to the comparison between the two final listed genotypes (SCD vs. SCD:TgTR2/TR4) by Student t test.