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FoxO-induced G1/S arrest of the cell cycle. Isotretinoin-mediated upregulation of cell cycle inhibitors p21 and p27 by FoxO binding to their promoters. Growth factor-mediated nuclear export of FoxO proteins with consecutive downregualtion of p21, p27 and p130. ATRA, all-trans-retinoic acid; Akt, Akt kinase; PI3K, phosphoinositol-3 kinase; IGF-1, insulin-like growth factor-1.
