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Isotretinoin-mediated overexpression of FoxO proteins and divergence of β-cateinin signaling from Lef1/Tcf-induced transcription by increased binding of β-catenin to nuclear FoxO proteins. ATRA, all-trans-retinoic acid; CRABP2, cellular retinoic acid binding protein-2; Wnts, Wingless proteins; LRP5/6, low density receptor-related proteins 5/6; Frizzled, Wnt receptor Frizzled; β, β-catenin; Lef1, lymphoid enhancer-binding factor-1; Tcf, T cell factor.
