Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Isotretinoin's effect on the CNS is mediated by FoxO1 upregulation. in the hypothalamus FoxO1 inhibits neurogenesis associated with the risk of mood changes. FoxO1 suppresses the expression of proopiomelanocortin (POMC) and carboxypeptidase E (Cpe). This results in reduced formation of α-melanocyte stimulating hormone (α-MSH) and general suppression of the hypothalamic-pituitary-axis (HPA) with decreased pituitary hormone secretion.
