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. 2011 Jul 1;3(3):166–174. doi: 10.4161/derm.3.3.15332

Figure 1.

Figure 1

Histopathology of the embryonic and adul skin of genetically modified mice with GR gain- and loss-of-function. Histopathology of the embryonic (upper part) and adul skin (lower part) of genetically modified mice with GR gain- and loss-of-function. Upper part, immunostaining using an anti-GR specific antibody in paraffin-embedded E18.5 skin sections. Lower part, hematoxylin/eosin staining in paraffin-embedded adult skin sections. K5-GR, Keratinocyte-targeted expression of WT GR. K5-GR-TR, Keratinocyte-targeted expression of the mutant form of GR P493R/A494S. K14-cre-ERT2//GRloxP/loxP, Keratinocyte-specific inactivation of GR induced in the adult mouse.