Table 2.
Selected ontologies of commonly downregulated genes
| Term | Genes a | Gene set on the array | Z-score |
|---|---|---|---|
| Biological process | |||
| Cell cycle | 20 | 957 | 4.42 |
| Spindle organizationb | 4 | 54 | 5.31 |
| DNA metabolic process | 18 | 559 | 6.32 |
| DNA replicationb | 13 | 228 | 8.13 |
| DNA-dependent DNA replicationb | 5 | 71 | 5.75 |
| DNA-dependent DNA replication initiationb | 3 | 25 | 6.13 |
| Cellular component | |||
| Chromosomal part | 13 | 381 | 5.57 |
| Condensed chromosome kinetochoreb | 4 | 69 | 4.52 |
| Replication forkb | 3 | 33 | 5.2 |
| Molecular function | |||
| Transmembrane receptor protein tyrosine kinase activity | 4 | 64 | 4.81 |
| DNA helicase activity | 3 | 41 | 4.6 |
| Insulin-like growth factor binding | 3 | 24 | 6.32 |
aNumber of genes differentially expressed within the assigned ontology. bSubcategory within a given ontology.