Table 4.
Single-nucleotide polymorphisms associated with serum prolactin levels in the Polish Breast Cancer Studya
| Single-nucleotide polymorphism | Number | Geometric meanb | 95% CI | P trend |
|---|---|---|---|---|
| Premenopausal controls | ||||
| PRLR | ||||
| rs62355518 | ||||
| AA | 140 | 11.16 | 8.81-14.15 | 0.01 |
| AG | 55 | 8.90 | 6.87-11.51 | |
| GG | 5 | 10.61 | 6.60-17.05 | |
| rs10941235 | ||||
| GG | 101 | 11.05 | 8.66-14.08 | 0.01 |
| AG | 90 | 9.24 | 7.21-11.85 | |
| AA | 12 | 9.37 | 6.57-13.37 | |
| rs1610218 | ||||
| GG | 192 | 10.47 | 8.26-13.28 | 0.01 |
| AG | 13 | 6.95 | 4.81-10.03 | |
| AA | 0 | |||
| rs34024951 | ||||
| GG | 170 | 10.25 | 8.07-13.02 | 0.02 |
| AG | 34 | 8.38 | 6.27-11.19 | |
| AA | 1 | 6.60 | 2.53-17.21 | |
| rs9292575 | ||||
| CC | 162 | 10.07 | 7.97-12.71 | 0.03 |
| AC | 39 | 13.38 | 10.10-17.72 | |
| AA | 3 | 7.32 | 4.19-12.80 | |
| Postmenopausal controls | ||||
| PRL | ||||
| rs849872 | ||||
| AA | 300 | 7.63 | 6.23-9.35 | 0.01 |
| AG | 126 | 8.34 | 6.76-10.28 | |
| GG | 13 | 9.69 | 7.10-13.24 |
aA complete list of single-nucleotide polymorphism associations with serum prolactin concentrations can be found in Supplementary tables S3a and S3b in Additional file 1. bAdjusted for age, study site, time of blood collection, and time since last period (premenopausal only). CI, confidence interval; PRL, prolactin (gene); PRLR, prolactin receptor (gene).