Table 2.
Correlation analysis of intrinsic subtypes with clinicopathological parameters, Treg and CXCL12 expression (n = 456)
| Luminal (n = 289) | HER2 (n = 75) | Basal-like (n = 62) | Negative (n = 30) | P-value | |
|---|---|---|---|---|---|
| Patient age | |||||
| Median (years) | 56.0 | 55.2 | 54.0 | 52.7 | 0.64 |
| Tumour size | |||||
| Median | 18.0 | 22.0 | 22.5 | 20.5 | 0.40 |
| Tumour grade | < 0.001 | ||||
| 1 | 71 (25%) | 4 (5%) | 2 (3%) | 4 (13%) | |
| 2 | 156 (55%) | 16 (22%) | 12 (20%) | 12 (40%) | |
| 3 | 58 (20%) | 54 (73%) | 47 (77%) | 14 (47%) | |
| Nodal status | 0.75 | ||||
| Negative | 162 (56%) | 40 (54%) | 34 (55%) | 17 (57%) | |
| Positive | 125 (44%) | 34 (46%) | 28 (45%) | 13 (43%) | |
| Treg | < 0.001 | ||||
| < 15 | 159 (62%) | 28 (39%) | 19 (25%) | 23 (92%) | |
| ≥15 | 99 (38%) | 43 (61%) | 36 (75%) | 2 (8%) | |
| median | 7.64 | 33.54 | 25.46 | 0.83 | |
| CXCL12 | 0.050 | ||||
| Negative | 36 (26%) | 22 (47%) | 11 (41%) | 6 (35%) | |
| Positive | 102 (74%) | 25 (53%) | 16 (59%) | 11 (65%) |
Treg, regulatory T cells.