. 2011 Jul;25(7):2418–2432. doi: 10.1096/fj.10-180299

Table 2.

Gene-expression profiles in 6-wk-old mice

Gene	Accession no.	Dmp1-Cre; Pkd1^flox/+	Pkd1^flox/m1Bei	Dmp1-Cre; Pkd1^flox/m1Bei	P value
Osteoblast lineage
Runx2-II	NM_009820	0.77 ± 0.07^*	0.75 ± 0.06^*	0.52 ± 0.17^*^,#	0.0007
Runx2-I	D14636	1.06 ± 0.63	0.96 ± 0.31	0.94 ± 0.17	0.9504
Runx2	NM_009820	0.73 ± 0.08^*	0.69 ± 0.13^*	0.47 ± 0.15^*^,#	<0.0001
Osteocalcin	NM_007541	0.69 ± 0.12^*	0.66 ± 0.11^*	0.41 ± 0.11^*^,#	0.0002
Osteopontin	AF515708	0.72 ± 0.14^*	0.69 ± 0.16^*	0.39 ± 0.19^*^,#	0.0001
Bsp	NM_008318	0.70 ± 0.12^*	0.71 ± 0.07^*	0.56 ± 0.11^*^,#	<0.0001
Opg	MMU94331	0.75 ± 0.12^*	0.72 ± 0.13^*	0.65 ± 0.12^*	0.0200
Rank ligand	NM_011613	0.70 ± 0.14^*	0.71 ± 0.13^*	0.41 ± 0.17^*^,#	0.0003
Mmp13	NM_008607	0.66 ± 0.14^*	0.61 ± 0.12^*	0.37 ± 0.16^*^,#	<0.0001
Dmp1	MMU242625	0.63 ± 0.17^*	0.60 ± 0.16^*	0.29 ± 0.05^*^,#	0.0004
Phex	NM_011077	0.67 ± 0.14^*	0.68 ± 0.05^*	0.54 ± 0.11^*^,#	<0.0001
Sost	NM_024449	1.62 ± 0.47^*	1.67 ± 0.11^*	1.64 ± 0.31^*	0.0013
Osteoclast
Trap	NM_007388	0.65 ± 0.16^*	0.63 ± 0.21^*	0.31 ± 0.12^*^,#	0.0004
Mmp9	NM_013599	0.71 ± 0.11^*	0.77 ± 0.09^*	0.33 ± 0.09^*	<0.0001
Chondrocyte
Collagen II	NM_031163	1.28 ± 0.89	1.30 ± 0.85	0.97 ± 0.38	0.7666
VegfA	NM_009505	1.02 ± 0.55	1.01 ± 0.29	1.19 ± 0.62	0.8889
Adipocyte
PPARγ	NM_009505	1.41 ± 0.35^*	1.56 ± 0.38^*	1.76 ± 0.41^*	0.00168
aP2	NM_024406	1.46 ± 0.16^*	1.57 ± 0.23^*	1.95 ± 0.26^*^,#	0.0058

Data are means ± sd from 5–6 tibias of 6-wk-old individual mice and expressed as x-fold change relative to the housekeeping gene cyclophilin A, subsequently normalized to control (Pkd1^flox/+) mice.

P < 0.05 vs. Pkd1^flox/+;

P < 0.05 vs. Dmp1-Cre;Pkd1^flox/+ and Pkd1^flox/m1Bei.