Table 3.

Biochemistry analysis of serum in 6- and 16-wk-old mice

Serum value	Pkd1flox/+	Pkd1Dmp1−cKO
BUN (mg/dl)
6 wk	31 ± 4.4	30 ± 4.8
16 wk	29 ± 5.1	28 ± 3.5
Ca (mg/dl)
6 wk	8.9 ± 0.26	9.1 ± 0.27
16 wk	8.7 ± 0.39	9.0 ± 0.22
P (mg/dl)
6 wk	8.1 ± 0.33	8.0 ± 0.48
16 wk	7.6 ± 0.61	7.2 ± 0.34
Osteocalcin (ng/ml)
6 wk	106 ± 12	39 ± 7*
16 wk	14.4 ± 5.1	12.3 ± 5.5
OPG (ng/ml)
6 wk	2.4 ± 0.33	2.7 ± 0.53
16 wk	2.5 ± 0.34	2.2 ± 0.42
RankL (pg/ml)
6 wk	179 ± 29	115 ± 28*
16 wk	110 ± 14	91 ± 7*
TRAP (U/L)
6 wk	3.4 ± 0.73	2.0 ± 0.29*
16 wk	2.7 ± 0.34	2.1 ± 0.42*

Data are means ± sd from 5 to 6 individual mice. Osteocalcin is produced by osteoblasts; TRAP is produced by osteoclasts.

^*P < 0.05 vs. Pkd1^flox/+.