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. 2011 Nov 1;25(21):2278–2290. doi: 10.1101/gad.171645.111

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Figure 7. — Regulation of Bax-mediated bacterial lysis by Bcl-xL and tBid. (A) Suppression of miniBaxH3A-mediated bacterial lysis by Bcl-xL. Lysis curves of F-miniBaxH3A lysogens carrying the indicated plasmids were measured at a 15-min interval. The expression of Bcl-xL and Bcl-xLmt8 at 15 min was detected using an α-Bcl-xL antibody, and the expression of miniBaxH3A was detected using an α-Flag antibody. (B) Suppression of BaxΔH6-mediated bacterial lysis by Bcl-xL. (C) Lysis phenotypes of sam7 lysogen carrying the indicated plasmids. The expression of tBid, its mutants, and Bax at 60 min was detected by Western blot with an α-Flag antibody. (D) Lysis phenotypes of F-Bax lysogen carrying indicated plasmids. (E) A diagram depicting the functional homology between MOMP and hole formation in bacterial membrane.