Table 2.
Evolution of microcirculatory scores and hemodynamic and perfusion parameters during the study
| Parameter | Baseline | After 12 hours of HVHF | 6 hours after HVHF |
|---|---|---|---|
| MAP, mm Hg | 67.5 ± 4.3 | 74.5 ± 6.8a | 76.0 ± 9.4a |
| Norepinephrine, μg/kg per min | 0.49 ± 0.21 | 0.44 ± 0.45 | 0.26 ± 0.38 |
| CI, L/min per m2 | 4.06 ± 1.11 | 3.68 ± 1.36 | 3.55 ± 1.12 |
| SmvO2, percentage | 72.4 ± 1.7 | 71.4 ± 7.0 | 76.1 ± 6.0 |
| Lactate, mmol/L | 5.38 ± 2.99 | 3.66 ± 2.39a | 3.64 ± 3.89a |
| IDO2, mL/min per m2 | 543 ± 211 | 483 ± 350 | 475 ± 173 |
| IVO2, mL/min per m2 | 137 ± 63 | 135 ± 101 | 108 ± 40 |
| O2ER, percentage | 26 ± 12.3 | 27.8 ± 0.7 | 23.1 ± 6.0 |
| SVRI, dyne-s/cm5 per m2 | 1,027 ± 268 | 1,373 ± 408b | 1,432 ± 375b |
| Hemoglobin, g/dL | 10.1 ± 1.4 | 10.2 ± 2 | 10.2 ± 1.3 |
| Core temperature, °C | 38.1 ± 1 | 37.2 ± 0.9 | 37.5 ± 1.1 |
| SOFA score | 12.8 ± 1.7 | 13.1 ± 2.1 | 12.4 ± 2.5 |
| TVD, n/mm | 13.1 ± 1.9 | 13.6 ± 3.3 | 14.2 ± 3.8 |
| PVD, n/mm | 9.6 ± 2.5 | 11.1 ± 3.0 | 12.1 ± 4.3 |
| PPV, percentage | 73.6 ± 15.6 | 81.7 ± 13.3c | 83.2 ± 14.7c |
| MFId | 2.15 (1.64-2.28) | 2.5 (1.96-2.7)b | 2.5 (2.31-2.63)b |
| Het MFId | 0.44 (0.36-0.47) | 0.4 (0.12-0.65) | 0.29 (0.18-0.32) |
aP < 0.05 versus baseline; bP < 0.01 versus baseline; cP < 0.06 versus baseline; ddata are presented as mean ± standard deviation or as median and 25th-75th percentiles. CI, cardiac index; Het MFI, heterogeneity of microvascular flow index; HVHF, high-volume hemofiltration; IDO2, oxygen delivery index; IVO2, oxygen consumption index; MAP, mean arterial pressure; MFI, microvascular flow index; n/mm, number of vessels per millimeter; O2ER, oxygen extraction ratio; PPV, proportion of perfused vessels; PVD, perfused vascular density; SmvO2, mixed venous oxygen saturation; SOFA, Sequential Organ Failure Assessment; SVRI, systemic vascular resistance index; TVD, total vascular density.