Table 1.
Systemic hemodynamic measurements and pulmonary hemodynamic measurements
| Parameter | Group | Time | ||
|---|---|---|---|---|
| 0 h | 4 h | 6 h | ||
| Weight (kg) | Control | 30.4 ± 0.69 | ||
| LPS + Vehicle | 31.0 ± 0.58 | |||
| LPS + Netrin i.v. | 30.2 ± 0.20 | |||
| LPS + Netrin inh. | 29.8 ± 0.49 | |||
| CI (ml min-1 kg-1) | Control | 166 ± 3.0 | 167 ± 5.1 | 156 ± 10.4 |
| LPS + Vehicle | 170 ± 5.1 | 136 ± 10.5 | 122 ± 7.3* | |
| LPS + Netrin i.v. | 163 ± 9.2 | 128 ± 11.9 | 114 ± 9.4* | |
| LPS + Netrin inh | 160 ± 3.4 | 130 ± 11.9 | 118 ± 8.4* | |
| MAP (mmHg) | Control | 68 ± 3.7 | 77 ± 4.9 | 84 ± 3.7 |
| LPS + Vehicle | 75 ± 6.0 | 89 ± 3.2 | 119 ± 6.4* | |
| LPS + Netrin i.v. | 78 ± 6.5 | 97 ± 6.9* | 124 ± 7.0* | |
| LPS + Netrin inh. | 86 ± 6.7 | 93 ± 2.7 | 118 ± 4.5* | |
| MPAP (mmHg) | Control | 16 ± 1.4 | 17 ± 1.4 | 17 ± 1.8 |
| LPS + Vehicle | 17 ± 0.7 | 31 ± 1.8* | 31 ± 2.0* | |
| LPS + Netrin i.v. | 18 ± 0.8 | 31 ± 2.0* | 34 ± 2.3* | |
| LPS + Netrin inh | 16 ± 0.5 | 28 ± 2.5* | 31 ± 3.3* | |
| SVR (dyne*s*cm5 kg-1) | Control | 34 ± 1.6 | 39 ± 3.7 | 47 ± 5.6 |
| LPS + Vehicle | 36 ± 3.6 | 54 ± 3.8 | 80 ± 8.1* | |
| LPS + Netrin i.v. | 41 ± 4.6 | 66 ± 7.8* | 95 ± 11.4* | |
| LPS + Netrin inh | 47 ± 4.2 | 64 ± 6.2* | 88 ± 7.0* | |
| PVR (dyne*s*cm5 kg-1) | Control | 6.5 ± 0.6 | 6.7 ± 0.4 | 7.2 ± 0.7 |
| LPS + Vehicle | 6.6 ± 0.4 | 16.6 ± 2.3* | 16.9 ± 1.4* | |
| LPS + Netrin i.v. | 7.1 ± 0.5 | 16.6 ± 2.4* | 20.6 ± 3.0* | |
| LPS + Netrin inh. | 6.8 ± 0.4 | 15.5 ± 2.8* | 18.9 ± 2.1* | |
| PCWP (mmHg) | Control | 3.9 ± 0.4 | 3.9 ± 0.5 | 4.0 ± 0.5 |
| LPS + Vehicle | 3.2 ± 0.6 | 5.1 ± 0.9 | 6.6 ± 1.9* | |
| LPS + Netrin i.v. | 4.4 ± 0.3 | 7.0 ± 0.5* | 8.0 ± 0.5* | |
| LPS + Netrin inh | 4.4 ± 0.5 | 6.8 ± 0.5* | 7.6 ± 0.5* | |
| ITBVI (ml kg-1) | Control | 33.3 ± 1.5 | 33.0 ± 0.7 | 30.8 ± 1.6 |
| LPS + Vehicle | 31.9 ± 1.8 | 28.0 ± 1.3 | 32.0 ± 3.0 | |
| LPS + Netrin i.v. | 34.4 ± 3.1 | 31.9 ± 2.0 | 35.5 ± 2.1 | |
| LPS + Netrin inh. | 32.1 ± 1.3 | 29.0 ± 0.8 | 33.0 ± 0.6 | |
| EVLWI (ml kg-1) | Control | 5.5 ± 0.4 | 6.0 ± 0.6 | 6.5 ± 0.5 |
| LPS + Vehicle | 5.7 ± 0.7 | 9.1 ± 2.1 | 9.7 ± 1.3* | |
| LPS + Netrin i.v. | 5.1 ± 0.7 | 7.5 ± 0.4 | 11.9 ± 1.4* | |
| LPS + Netrin inh. | 4.8 ± 0.4 | 6.3 ± 0.7 | 8.1 ± 1.3* | |
Measurements are compared in the control, vehicle and netrin-1 treatment groups 4 hours and 6 hours after the end of treatment (data are means ± SEM and indexed in body weight; P < 0.05; *versus control group). Cardiac index (CI), mean arterial pressure (MAP), mean pulmonary arterial pressure (MPAP), systemic vascular resistance index (SVR), pulmonary vascular resistance index (PVR), pulmonary capillary wedge pressure (PCWP), central venous pressure (CVP), intrathoracic blood volume index (ITBVI), extravascular lung water index (EVLWI).