Table 1.
AC-Off (n = 12) |
AC-On (n = 13) |
p | |||||
---|---|---|---|---|---|---|---|
Pre-TAC | 4 Week after TAC | Change | Pre-TAC | 4 Week after TAC | Change | ||
HR (bpm) | 489 ± 18 | 484 ± 14 | –5 ± 23 | 469 ± 17 | 474 ± 22 | 5 ± 27 | 0.85 |
LVEDD (mm) | 3.86 ± 0.08 | 4.40 ± 0.07 | 0.55 ± 0.08 | 3.77 ± 0.06 | 4.12 ± 0.07 | 0.35 ± 0.04 | 0.04 |
LVESD (mm) | 2.53 ± 0.07 | 3.36 ± 0.09 | 0.83 ± 0.11 | 2.50 ± 0.06 | 2.93 ± 0.06 | 0.43 ± 0.07 | 0.006 |
IVS (mm) | 0.67 ± 0.02 | 0.99 ± 0.05 | 0.32 ± 0.04 | 0.66 ± 0.01 | 0.98 ± 0.04 | 0.32 ± 0.03 | 0.97 |
PW (mm) | 0.66 ± 0.02 | 0.95 ± 0.04 | 0.28 ± 0.03 | 0.63 ± 0.02 | 0.92 ± 0.04 | 0.29 ± 0.04 | 0.85 |
FS (%) | 35 ± 2 | 24 ± 1 | –11 ± 2 | 34 ± 1 | 29 ± 1 | –5 ± 2 | 0.02 |
Values represent mean ± SE. The p-value was calculated from Student's t-test (unpaired, 2-tailed) comparing changes in each parameter (4 week after TAC data minus pre-TAC data). AC, adenylyl cyclase; LVEDD, LV end-diastolic dimension; LVESD, LV end-systolic dimension; IVS, interventricular septal diastolic thickness; PW, posterior diastolic wall thickness; FS, fractional shortening.