. Author manuscript; available in PMC: 2011 Nov 17.

Published in final edited form as: Biochem Biophys Res Commun. 2010 Dec 30;405(3):349–355. doi: 10.1016/j.bbrc.2010.12.113

Table 1.

Echocardiography: effect of AC6 activation on LV size and function during TAC.

	AC-Off (n = 12)			AC-On (n = 13)			p
	Pre-TAC	4 Week after TAC	Change	Pre-TAC	4 Week after TAC	Change
HR (bpm)	489 ± 18	484 ± 14	–5 ± 23	469 ± 17	474 ± 22	5 ± 27	0.85
LVEDD (mm)	3.86 ± 0.08	4.40 ± 0.07	0.55 ± 0.08	3.77 ± 0.06	4.12 ± 0.07	0.35 ± 0.04	0.04
LVESD (mm)	2.53 ± 0.07	3.36 ± 0.09	0.83 ± 0.11	2.50 ± 0.06	2.93 ± 0.06	0.43 ± 0.07	0.006
IVS (mm)	0.67 ± 0.02	0.99 ± 0.05	0.32 ± 0.04	0.66 ± 0.01	0.98 ± 0.04	0.32 ± 0.03	0.97
PW (mm)	0.66 ± 0.02	0.95 ± 0.04	0.28 ± 0.03	0.63 ± 0.02	0.92 ± 0.04	0.29 ± 0.04	0.85
FS (%)	35 ± 2	24 ± 1	–11 ± 2	34 ± 1	29 ± 1	–5 ± 2	0.02

Values represent mean ± SE. The p-value was calculated from Student's t-test (unpaired, 2-tailed) comparing changes in each parameter (4 week after TAC data minus pre-TAC data). AC, adenylyl cyclase; LVEDD, LV end-diastolic dimension; LVESD, LV end-systolic dimension; IVS, interventricular septal diastolic thickness; PW, posterior diastolic wall thickness; FS, fractional shortening.