Table 2.
–Doxycycline (n = 7) |
+Doxycycline (n = 7) |
p | |||||
---|---|---|---|---|---|---|---|
Pre-TAC | 4 Week after TAC | Change | Pre-TAC | 4 Week after TAC | Change | ||
HR (bpm) | 484 ± 12 | 503 ± 11 | 19 ± 12 | 498 ± 13 | 504 ± 14 | –1 ± 16 | 0.53 |
LVEDD (mm) | 3.89 ± 0.08 | 4.33 ± 0.10 | 0.44 ± 0.14 | 3.86 ± 0.08 | 4.31 ± 0.06 | 0.42 ± 0.09 | 0.86 |
LVESD (mm) | 2.56 ± 0.11 | 3.35 ± 0.12 | 0.79 ± 0.19 | 2.54 ± 0.11 | 3.32 ± 0.11 | 0.73 ± 0.11 | 1.0 |
IVS (mm) | 0.67 ± 0.01 | 0.97 ± 0.04 | 0.30 ± 0.05 | 0.69 ± 0.01 | 0.95 ± 0.03 | 0.26 ± 0.02 | 0.88 |
PW (mm) | 0.63 ± 0.03 | 0.94 ± 0.03 | 0.31 ± 0.04 | 0.66 ± 0.01 | 0.91 ± 0.02 | 0.27 ± 0.02 | 0.72 |
FS (%) | 34 ± 2 | 23 ± 2 | –12 ± 2 | 34 ± 2 | 23 ± 2 | –11 ± 2 | 0.92 |
Values represent mean ± SE. The p-value was calculated from Student's t-test (unpaired, 2-tailed) comparing changes in each parameter (4 week after TAC data minus pre- TAC data). AC, adenylyl cyclase; LVEDD, LV end-diastolic dimension; LVESD, LV end-systolic dimension; TVS, interventricular septal diastolic thickness; PW, posterior diastolic wall thickness; FS, fractional shortening.