. Author manuscript; available in PMC: 2011 Nov 17.

Published in final edited form as: Biochem Biophys Res Commun. 2010 Dec 30;405(3):349–355. doi: 10.1016/j.bbrc.2010.12.113

Table 2.

Echocardiography: transgene-negative siblings ± doxycycline.

	–Doxycycline (n = 7)			+Doxycycline (n = 7)			p
	Pre-TAC	4 Week after TAC	Change	Pre-TAC	4 Week after TAC	Change
HR (bpm)	484 ± 12	503 ± 11	19 ± 12	498 ± 13	504 ± 14	–1 ± 16	0.53
LVEDD (mm)	3.89 ± 0.08	4.33 ± 0.10	0.44 ± 0.14	3.86 ± 0.08	4.31 ± 0.06	0.42 ± 0.09	0.86
LVESD (mm)	2.56 ± 0.11	3.35 ± 0.12	0.79 ± 0.19	2.54 ± 0.11	3.32 ± 0.11	0.73 ± 0.11	1.0
IVS (mm)	0.67 ± 0.01	0.97 ± 0.04	0.30 ± 0.05	0.69 ± 0.01	0.95 ± 0.03	0.26 ± 0.02	0.88
PW (mm)	0.63 ± 0.03	0.94 ± 0.03	0.31 ± 0.04	0.66 ± 0.01	0.91 ± 0.02	0.27 ± 0.02	0.72
FS (%)	34 ± 2	23 ± 2	–12 ± 2	34 ± 2	23 ± 2	–11 ± 2	0.92

Values represent mean ± SE. The p-value was calculated from Student's t-test (unpaired, 2-tailed) comparing changes in each parameter (4 week after TAC data minus pre- TAC data). AC, adenylyl cyclase; LVEDD, LV end-diastolic dimension; LVESD, LV end-systolic dimension; TVS, interventricular septal diastolic thickness; PW, posterior diastolic wall thickness; FS, fractional shortening.