. Author manuscript; available in PMC: 2011 Nov 17.

Published in final edited form as: Biochem Biophys Res Commun. 2010 Dec 30;405(3):349–355. doi: 10.1016/j.bbrc.2010.12.113

Table 3.

Hemodynamic assessment.

	AC-Off (n = 8)			AC-On (n = 8)			p
	Baseline	+ISO	Change	Baseline	+ISO	Change
HR (bpm)	422 ± 31	578 ± 34	155 ± 16	430 ± 28	602 ± 17	172 ± 27	0.59
LVSP (mm Hg)	101 ± 12	128 ± 15	26 ± 8	100 ± 13	143 ± 20	43 ± 16	0.37
Max dP/dt (mm Hg/s)	5122 ± 785	9579 ± 1039	4457 ± 813	5129 ± 632	12,591 ± 644	7462 ± 887	0.026
Min dP/dt (mm Hg/s)	–4274 ± 697	–5497 ± 786	–1223 ± 725	–4552 ± 725	–9049 ± 1041	–4497 ± 937	0.015
LVEDP (mm Hg)	9.4 ± 1.2	7.9 ± 1.1	–1.5 ± 0.3	8.6 ± 1.1	5.9 ± 0.8	–2.8 ± 0.4	0.023
CO (mL/min)	6.6 ± 0.7	9.5 ± 1.1	2.8 ± 0.6	6.1 ± 0.8	11.7 ± 10.9	5.5 ± 1.0	0.042
Tau (ms)	6.5 ± 0.5	5.5 ± 0.4	–1.0 ± 0.3	7.1 ± 0.4	5.0 ± 0.2	–2.1 ± 0.3	0.019

Values represent mean ± SE. The p-value was calculated Student's t-test (unpaired, 2-tailed) comparing changes in each parameter (+ISO data minus baseline data). AC, adenylyl cyclase; HR, heart rate; LVSP, LV systolic pressure; LVEDP, LV end-diastolic pressure; CO, cardiac output; ISO, isoproterenol, 1 μg/g, iv.