Table 3.
AC-Off (n = 8) |
AC-On (n = 8) |
p | |||||
---|---|---|---|---|---|---|---|
Baseline | +ISO | Change | Baseline | +ISO | Change | ||
HR (bpm) | 422 ± 31 | 578 ± 34 | 155 ± 16 | 430 ± 28 | 602 ± 17 | 172 ± 27 | 0.59 |
LVSP (mm Hg) | 101 ± 12 | 128 ± 15 | 26 ± 8 | 100 ± 13 | 143 ± 20 | 43 ± 16 | 0.37 |
Max dP/dt (mm Hg/s) | 5122 ± 785 | 9579 ± 1039 | 4457 ± 813 | 5129 ± 632 | 12,591 ± 644 | 7462 ± 887 | 0.026 |
Min dP/dt (mm Hg/s) | –4274 ± 697 | –5497 ± 786 | –1223 ± 725 | –4552 ± 725 | –9049 ± 1041 | –4497 ± 937 | 0.015 |
LVEDP (mm Hg) | 9.4 ± 1.2 | 7.9 ± 1.1 | –1.5 ± 0.3 | 8.6 ± 1.1 | 5.9 ± 0.8 | –2.8 ± 0.4 | 0.023 |
CO (mL/min) | 6.6 ± 0.7 | 9.5 ± 1.1 | 2.8 ± 0.6 | 6.1 ± 0.8 | 11.7 ± 10.9 | 5.5 ± 1.0 | 0.042 |
Tau (ms) | 6.5 ± 0.5 | 5.5 ± 0.4 | –1.0 ± 0.3 | 7.1 ± 0.4 | 5.0 ± 0.2 | –2.1 ± 0.3 | 0.019 |
Values represent mean ± SE. The p-value was calculated Student's t-test (unpaired, 2-tailed) comparing changes in each parameter (+ISO data minus baseline data). AC, adenylyl cyclase; HR, heart rate; LVSP, LV systolic pressure; LVEDP, LV end-diastolic pressure; CO, cardiac output; ISO, isoproterenol, 1 μg/g, iv.