Table 3.
Factors associated with 30-day pneumonia-related mortality in patients with ICU-acquired pneumonia determined by multivariable analysisa
| Variable | Adjusted hazard ratiob | 95% CI | P value |
|---|---|---|---|
| Inadequacy of antibiotics | 2.145 | 0.483 to 9.536 | 0.316 |
| Non-de-escalation of antibiotics | 3.988 | 0.047 to 6.985 | 0.245 |
| Baseline APACHE II score (reference score <19) | 0.198 | ||
| 20 to 23 | 2.528 | 0.609 to 10.493 | 0.201 |
| ≥24 | 7.611 | 0.615 to 94.179 | 0.114 |
| 5-day APACHE II score (reference score <19) | 0.011 | ||
| 20 to 23 | 4.934 | 0.974 to 25.003 | 0.054 |
| ≥24 | 12.839 | 2.359 to 69.883 | 0.003 |
| 5-day CPIS (reference score 4 to 6) | 0.017 | ||
| 7 to 9 | 2.154 | 0.361 to 12.861 | 0.400 |
| ≥10 | 26.782 | 2.180 to 329.011 | 0.010 |
aICU, intensive care unit; 95% CI, 95% confidence interval; APACHE II, Acute Physiology and Chronic Health Evaluation II; CPIS, Clinical Pulmonary Infection Score; bCox proportional hazard regression analysis was used to determine the relationship between mortality and independent baseline variables identified in univariable analysis, including inadequacy of initial antibiotics, de-escalation of antibiotics, baseline APACHE II score, 5-day APACHE II score and 5-day CPIS.