Table 1.

On-going studies

On-going study	Clinical group of trauma patients	Intervention details	Comparator details	Primary endpoint	Target number to be recruited	Expected end date
CRISTAL: Colloids versus crystalloids for resuscitation of critically ill patients	ITU patients, fluid resuscitation	Colloids	Crystalloids	28 day mortality	3,010	March 2011
High versus low MAP for trauma patients undergoing surgery	Adults, SBP < 90 mmHg, requiring laparotomy or thoracotomy,	Target minimum mean arterial BP 50 mmHg	Target minimum mean arterial BP 65 mmHg	30 day survival	271	July 2011
FIRST: Colloids versus crystalloids for resuscitation of trauma patients	Adults, requiring ≥3 litres of fluid	HES 130/0.4 in saline (Voluven)	0.9% saline	Fluid volumes over first 24 hours	140	December 2009
Formula-driven vs. laboratory-guided transfusion in bleeding trauma patients: a feasibility study	Adults, requiring four units of RBC in two hours and ongoing blood loss	FFP:RBC:platelets ratio of 1:1:1 - formula	Standard of care	Protocol compliance at 12 hours	70	October 2011

FFP, fresh frozen plasma; GCS, Glasgow coma score; ITU, intensive care unit; MAP, mean arterial pressure; RBC, red blood cell; SBP, systolic blood pressure.