Table 2.

Terminated studies

Study	Clinical group of trauma patients	Intervention details	Comparator details	Primary endpoint	Completion/Termination date
Warming techniques for treatment of hypothermia in polytrauma	Adults, polytrauma, GCS > 9, ISS > 16 and ASCOT score = 2 to 50%	Endovascular catheter + forced air warming	Forced air warming	Morbidity during length of stay	Suspended July 2010. Insufficient numbers of patients recruited
Hypertonic fluids for resuscitation of hypovolemic shock	Adults, prehospital SBP ≤ 70, or prehospital SBP 71-90 and HR ≥108	Arm A: 7.5% hypertonic saline/6% Dextran-70 Arm B: 7.5% hypertonic saline three arm trial	Arm C: 0.9% normal saline	28-day survival	Terminated August 2009 - no difference in 28-day survival (futility). Analysis reported earlier but not higher mortality with hypertonic saline arms.
Low dose vasopressin versus placebo in Traumatic Shock Resuscitation	Adults, SBP < 90 mmHg	Bolus vasopressin 4 U, then continuous infusion 2.4 U/hour for five hours	Normal saline	To develop new resuscitation regimens	Terminated April 2009 - poor accrual rate

ASCOT, a severity characterization of trauma score; rFVIIa, recombinant activated factor VII; SBP, systolic blood pressure.