Table 2.
PD-1-related molecule expressions as mean of fluorescence intensity on leukocytes in septic shock patients and healthy volunteers
| CD4+ T cells | CD8+ T cells | Monocytes | |||||||
|---|---|---|---|---|---|---|---|---|---|
| PD-1 | PD-L1 | PD-L2 | PD-1 | PD-1 | PD-L1 | PD-L2 | |||
| Healthy volunteers | Median | 8.7 | 11.5 | 4.9 | 13.6 | 12.3 | 16.9 | 8.9 | |
| IQR | (7.8-10.5) | (10.1-12.0) | (4.5-5.6) | (11.1-20.4) | (10.1-15.8) | (15.3-18.2) | (7.7-9.8) | ||
| Median | 13.1 | 11.4 | 6.0 | 18.1 | 17.4 | 22.0 | 11.6 | ||
| Day 1-2 | IQR | (11.4-19.7) | (9.8-14.3) | (4.8-7.1) | (13.6-24.4) | (14.6-24.0) | (19.3-31.8) | (9.9-13.6) | |
| Septic shock patients | P value | <0.001 | 0.150 | 0.009 | 0.213 | <0.001 | <0.001 | <0.001 | |
| Median | 12.2 | 11.4 | 5.4 | 17.5 | 16.2 | 21.1 | 11.1 | ||
| Day 3-5 | IQR | (10.8-15.7) | (10.0-13.5) | (4.4-7.1) | (11.8-22.3) | (13.0-20.4) | (18.2-28.0) | (9.6-13.3) | |
| P value | <0.001 | 0.289 | 0.232 | 0.306 | <0.001 | <0.001 | <0.001 | ||
Programmed death-1 (PD-1)-related molecule expressions were measured on circulating CD4+ and CD8+ lymphocytes and monocytes in whole blood from healthy volunteers (n = 49) and septic shock patients at day 1 to 2 (n = 37) and at day 3 to 5 (n = 56) after the onset of shock. Results are presented as mean fluorescence intensity. A P value of less than 0.025 was considered statistically significant, and correction for the number of tests was performed (Mann-Whitney U test). IQR, interquartile range.