Table 2.
Pooled summary results of the prognostic value of right ventricular dysfunction markers
| Number of patients | Number of studies | Odds ratio | Sensitivity, % | Specificity, % | PLR | NLR | PPV, % | NPV, % | |
|---|---|---|---|---|---|---|---|---|---|
| TTE Death all-cause |
1,249 | 8 | 2.36 (1.3-4.3) | 74 (61-84) | 54 (51-56) | 1.4 (1.2-1.6) | 0.62 (0.41-0.92) | 7.6 (5.6-10) | 97.6 (96-98.6) |
| TTE PE-related death |
781 | 7 | 4.44 (1.75-11.3) | 92 (78-98) | 51 (48-55) | 1.65 (1.4-2) | 0.36 (0.2-0.8) | 8.4 (6-11) | 99 (98-100) |
| TTE SAE |
1,035 | 7 | 4.03 (2.76-5.9) | 77 (71-83) | 58 (54-61) | 1.73 (1.5-1.9) | 0.46 (0.3-0.6) | 30 (26-34) | 92 (89-94) |
| CT Death all-cause |
383 | 2 | 1.54 (0.7-3.4) | 46 (27-66) | 59 (54-64) | 1.3 (0.4-2) | 0.8 (0.6-1.2) | 8.3 (4.5-14) | 93 (89-96) |
| CT PE-related death |
277 | 2 | 2.17 (0.06-79) | 87.5 (47-100) | 48 (42-54) | 1.2 (0.25-6) | 0.51 (0.007-36) | 5 (2-9) | 99 (96-100) |
| CT SAE |
0 | 0 | - | - | - | - | - | - | - |
| BNP-ProBNP Death all-cause |
582 | 7 | 7.7 (2.9-20.2) | 96 (86-100) | 42 (38-46) | 1.5 (1.2-1.9) | 0.26 (0.1-0.6) | 13 (10-17) | 99 (97-100) |
| BNP-ProBNP PE-related death |
436 | 6 | 6.4 (2-20) | 97 (84-100) | 42 (37-47) | 1.5 (1.2-1.9) | 0.3 (0.1-0.7) | 12 (8-16) | 97 (84-100) |
| BNP-ProBNP SAE |
228 | 3 | 15.6 (3-82) | 100 (91-100) | 36 (30-44) | 1.5 (1.3-1.7) | 0.01 (0.02-0.5) | 26 (19-33) | 100 (91-100) |
Values are presented as numbers or as percentages (ranges). BNP-ProBNP, brain natriuretic peptide-N-terminal pro-brain natriuretic peptide; CT, computed tomography; NLR, negative likelihood ratio; NPV, negative predictive value; PE, pulmonary embolism; PLR, positive likelihood ratio; PPV, positive predictive value; SAE, serious adverse event; TTE, transthoracic echocardiography.