Table 1.

Metastatic GISTs in the central nervous system (CNS)

No.	Age/gender	Primary		CNS		Treatment for CNS tumor	Mutational status	Response of CNS tumor	Reference
		site	size (cm)	site	size (cm)
1	75/M	mesentery	ND	hemisphere	(infiltrative)	imatinib 800 mg/day	NA	CR	Brooks et al. [12], 2002
2	47/M	jejunum	7.5	left parasagittal lesion	ND	total resection, imatinib 400–800 mg/day	exon 9	PD	Hughes et al. [9], 2004
3	68/F	perisacral area	ND	right parietal lobe	3	total resection, imatinib	NA	SD	Kaku et al. [10], 2006
4	42/M	mesentery	8×6	right parietal lobe	3.5	total resection, radiotherapy 60 Gy, imatinib 600 mg/day	NA	PD	Puri et al. [4], 2006
5	49/F	mesentery	ND	left eye, brain	0.24	imatinib 400 mg/day	NA	PD	Gentile et al. [13], 2008
6	54/F	esophagus	11	left frontal lobe	5	complete resection, imatinib 400 mg/day	exon 11	SD	Hamada et al. [11], 2010
7	77/M	jejunum	3	right cerebral	2.4	total resection of left occipital lobe tumor, radiation therapy 39 Gy, imatinib 400 mg/day	no mutation in KIT, PDGFRα	PD	our case, 2011
				peduncle left occipital lobe	2

ND = Not determined; NA = no analysis; CR = complete response; PD = progressive disease; SD = stable disease.