Skip to main content
. 2010 Sep 2;2(6):596–606. doi: 10.1159/000317640

Fig. 3.

Fig. 3

Characterization of the covRS intact isolates ALAB49 (M53) and NS730 (M90), and the covS mutant isolates NS88.2 (M98.1) and A20 (M23), in comparison with the M1T1 reference strains 5448 and 5448AP. a The percent survival of GAS isolates during co-culture with human neutrophils in vitro. b The capacity of SpeB-positive isolates to phase-switch to a SpeB-negative phenotype was assessed following a 3-day subcutaneous passage in C57BL/J6 mice. Each data point represents the percent of SpeBnegative covRS mutants recovered from the infection site of each mouse (n = 10 mice per strain). Subcutaneous infection of humanized plasminogen transgenic AlbPLG1 (n = 10) 5448 (3.9 × 107 CFU/dose) (c), ALAB49 (3.7 × 108 CFU/dose) (d), NS730 (2.2 × 108 CFU/dose) (e), 5448AP (5.1 × 107 CFU/dose) (f), NS88.2 (2.0 × 107 CFU/dose) (g) and A20 (1.2 × 108 CFU/dose) (h).