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. 2011 Aug 15;10(16):2737–2741. doi: 10.4161/cc.10.16.16756

Figure 4.

Figure 4

In vivo detection of recurrent tumors after fluorescence-guided surgery. (A) Brightfield observation several weeks after fluorescence-guided surgery of OBP-401 GFP-labeled tumors. Disseminated disease re-emerged. (B) Fluorescence observation of field observed by brightfield in (A). (C) Merge of (A and B). The red box outlines a region of (D) below. (D) Detail of the boxed region of (C). Black line indicates the direction of cross-sections. (E) Histologic sections stained with H&E showing that GFP-labeled lesions are recurrent tumor tissues (arrow heads). x40 magnification. (F) Detail of the boxed region of (E). x200 magnification.