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. Author manuscript; available in PMC: 2011 Nov 17.
Published in final edited form as: Cancer Res. 2009 Jan 27;69(3):958–966. doi: 10.1158/0008-5472.CAN-08-2216

Figure 5.

Figure 5

HDAC inhibitors impair recruitment of Pol II by AR and alter the phase of transcriptional cycling. A, LNCaP cells were starved for 72 h and treated with vehicle, 1 nmol/L R1881, 1 μmol/L TSA, or the combination of the two. Cells were harvested after 4 h, and ChIP was performed using antibodies against either AR or Pol II. B, ChIP was performed as above against SRC1 and p300. C, LNCaP cells were treated with R1881, in the presence or absence of TSA, over a 4 h 40 min time course. At 20-min intervals, ChIP was performed.