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. 2011 Sep 29;6:127. doi: 10.1186/1748-717X-6-127

Table 4.

Comparison between the current study and Intergroup-0116

Current study INT-0116
Patient population

Median age, yrs 63 60

Male, % 60 72

T3-T4, % 77 68

N+, % 85 85

Toxicity

Most common toxicities Hem. + GI Hem. + GI

Grade 3 toxicity 35% 41%

Grade 4 toxicity 22% 32%

Hospitalizations 32% NA

Toxic deaths 1.8% 1%

Discontinuation due to toxicity 36% 31%

efficacy1

3-year-DFS 60% 48%

3-year-OS 61% 50%

Proportion of distant relapses2 60% 65%

Hem. = hematological, GI = gastrointestinal, DFS = disease free survival, OS = overall survival.

1Efficacy data from the current study is limited only to patients undergoing R0 resection.

2Proportion of distant relapses out of all relapses, including those combined with locoregional relapses.