Table 3.
KEGG Pathway analysis
| Outdegree/Betweenness Centrality | |||
|---|---|---|---|
| Cluster | KEGG pathway | Percentage | P-value |
| 3 | no pathway | ||
| 15 | B cell receptor signaling pathway | 11.5 | 8.00E-03 |
| 17 | RIG-I-like receptor signaling pathway | 21.1 | 6.30E-06 |
| Cytosolic DNA-sensing pathway | 15.8 | 5.30E-04 | |
| Toll-like receptor signaling pathway | 10.5 | 6.70E-02 | |
| 18 | Natural killer cell mediated cytotoxicity | 16.7 | 2.60E-03 |
| Graft-versus-host disease | 11.1 | 4.00E-02 | |
| Allograft rejection | 11.1 | 4.00E-02 | |
| 20 | drug metabolism | 10.8 | 1.30E-03 |
| 23 | Jak-STAT signaling pathway | 6.0 | 9.60E-03 |
| Lysosome | 4.8 | 2.80E-02 | |
| Cell adhesion molecules (CAMs) | 4.8 | 5.30E-02 | |
| 24 | Cytokine-cytokine receptor interaction | 22.7 | 4.50E-05 |
| Chemokine signaling pathway | 18.2 | 5.90E-04 | |
| NOD-like receptor signaling pathway | 13.6 | 1.70E-03 | |
| Cytosolic DNA-sensing pathway | 9.1 | 5.60E-02 | |
| Hematopoietic cell lineage | 9.1 | 8.50E-02 | |
| Toll-like receptor signaling pathway | 9.1 | 9.90E-02 | |
| 29 | Proteasome | 6.3 | 1.00E-03 |
| Apoptosis | 4.8 | 5.40E-02 | |
| Toll-like receptor signaling pathway | 4.8 | 6.80E-02 | |
| 33 | Aldosterone-regulated sodium reabsorption | 3.4 | 7.40E-03 |
| Indegree | |||
| Cluster | KEGG pathway | Percentage | P-value |
| 7 | DNA replication | 9.7 | 4.60E-09 |
| Mismatch repair | 5.6 | 9.40E-05 | |
| 8 | Apoptosis | 3.2 | 1.40E-02 |
| p53 signaling pathway | 2.4 | 6.00E-02 | |
| 9 | Chemokine signaling pathway | 8.9 | 8.80E-03 |
| Jak-STAT signaling pathway | 6.7 | 5.20E-02 | |
| 10 | Antigen processing and presentation | 8.7 | 2.40E-05 |
| Allograft rejection | 7.2 | 7.20E-04 | |
| Endocytosis | 8.7 | 1.00E-03 | |
| Viral myocarditis | 5.8 | 5.90E-03 | |
| 11 | Complement and coagulation cascades | 8.2 | 3.10E-05 |
| Cytokine-cytokine receptor interaction | 9.6 | 1.70E-03 | |
| 14 | Natural killer cell mediated cytotoxicity | 13.5 | 5.00E-08 |
| T cell receptor signaling pathway | 8.5 | 8.70E-04 | |
| Primary immunodeficiency | 5.4 | 5.70E-03 | |
| Cell adhesion molecules (CAMs) | 8.1 | 2.80E-03 | |
| Leukocyte transendothelial migration | 6.8 | 6.80E-03 | |
| Cytokine-cytokine receptor interaction | 8.1 | 1.90E-02 | |
| Cell adhesion molecules (CAMs) | 3.8 | 1.70E-02 | |
| Cytokine-cytokine receptor interaction | 8.1 | 1.90E-02 | |
| Cell adhesion molecules (CAMs) | 3.8 | 1.70E-02 | |
| 22 | DNA replication | 3.4 | 2.30E-03 |
| Cytokine-cytokine receptor interaction | 5.2 | 3.80E-02 | |
| 23 | Jak-STAT signaling pathway | 6.0 | 9.60E-03 |
| Cell adhesion molecules (CAMs) | 4.8 | 5.80E-02 | |
| 24 | Cytokine-cytokine receptor interaction | 22.7 | 5.40E-05 |
| Chemokine signaling pathway | 18.2 | 5.90E-04 | |
| NOD-like receptor signaling pathway | 13.6 | 1.70E-03 | |
| 32 | Cytokine-cytokine receptor interaction | 19.6 | 2.00E-09 |
| NOD-like receptor signaling pathway | 8.9 | 5.30E-05 | |
| Toll-like receptor signaling pathway | 8.9 | 1.30E-04 | |
All top scorer clusters, with regard to indegree, outdegree and betweenness centrality metrics, were checked for enriched KEGG pathways.