Table 3.
Outdegree/Betweenness Centrality | |||
---|---|---|---|
Cluster | KEGG pathway | Percentage | P-value |
3 | no pathway | ||
15 | B cell receptor signaling pathway | 11.5 | 8.00E-03 |
17 | RIG-I-like receptor signaling pathway | 21.1 | 6.30E-06 |
Cytosolic DNA-sensing pathway | 15.8 | 5.30E-04 | |
Toll-like receptor signaling pathway | 10.5 | 6.70E-02 | |
18 | Natural killer cell mediated cytotoxicity | 16.7 | 2.60E-03 |
Graft-versus-host disease | 11.1 | 4.00E-02 | |
Allograft rejection | 11.1 | 4.00E-02 | |
20 | drug metabolism | 10.8 | 1.30E-03 |
23 | Jak-STAT signaling pathway | 6.0 | 9.60E-03 |
Lysosome | 4.8 | 2.80E-02 | |
Cell adhesion molecules (CAMs) | 4.8 | 5.30E-02 | |
24 | Cytokine-cytokine receptor interaction | 22.7 | 4.50E-05 |
Chemokine signaling pathway | 18.2 | 5.90E-04 | |
NOD-like receptor signaling pathway | 13.6 | 1.70E-03 | |
Cytosolic DNA-sensing pathway | 9.1 | 5.60E-02 | |
Hematopoietic cell lineage | 9.1 | 8.50E-02 | |
Toll-like receptor signaling pathway | 9.1 | 9.90E-02 | |
29 | Proteasome | 6.3 | 1.00E-03 |
Apoptosis | 4.8 | 5.40E-02 | |
Toll-like receptor signaling pathway | 4.8 | 6.80E-02 | |
33 | Aldosterone-regulated sodium reabsorption | 3.4 | 7.40E-03 |
Indegree | |||
Cluster | KEGG pathway | Percentage | P-value |
7 | DNA replication | 9.7 | 4.60E-09 |
Mismatch repair | 5.6 | 9.40E-05 | |
8 | Apoptosis | 3.2 | 1.40E-02 |
p53 signaling pathway | 2.4 | 6.00E-02 | |
9 | Chemokine signaling pathway | 8.9 | 8.80E-03 |
Jak-STAT signaling pathway | 6.7 | 5.20E-02 | |
10 | Antigen processing and presentation | 8.7 | 2.40E-05 |
Allograft rejection | 7.2 | 7.20E-04 | |
Endocytosis | 8.7 | 1.00E-03 | |
Viral myocarditis | 5.8 | 5.90E-03 | |
11 | Complement and coagulation cascades | 8.2 | 3.10E-05 |
Cytokine-cytokine receptor interaction | 9.6 | 1.70E-03 | |
14 | Natural killer cell mediated cytotoxicity | 13.5 | 5.00E-08 |
T cell receptor signaling pathway | 8.5 | 8.70E-04 | |
Primary immunodeficiency | 5.4 | 5.70E-03 | |
Cell adhesion molecules (CAMs) | 8.1 | 2.80E-03 | |
Leukocyte transendothelial migration | 6.8 | 6.80E-03 | |
Cytokine-cytokine receptor interaction | 8.1 | 1.90E-02 | |
Cell adhesion molecules (CAMs) | 3.8 | 1.70E-02 | |
Cytokine-cytokine receptor interaction | 8.1 | 1.90E-02 | |
Cell adhesion molecules (CAMs) | 3.8 | 1.70E-02 | |
22 | DNA replication | 3.4 | 2.30E-03 |
Cytokine-cytokine receptor interaction | 5.2 | 3.80E-02 | |
23 | Jak-STAT signaling pathway | 6.0 | 9.60E-03 |
Cell adhesion molecules (CAMs) | 4.8 | 5.80E-02 | |
24 | Cytokine-cytokine receptor interaction | 22.7 | 5.40E-05 |
Chemokine signaling pathway | 18.2 | 5.90E-04 | |
NOD-like receptor signaling pathway | 13.6 | 1.70E-03 | |
32 | Cytokine-cytokine receptor interaction | 19.6 | 2.00E-09 |
NOD-like receptor signaling pathway | 8.9 | 5.30E-05 | |
Toll-like receptor signaling pathway | 8.9 | 1.30E-04 |
All top scorer clusters, with regard to indegree, outdegree and betweenness centrality metrics, were checked for enriched KEGG pathways.