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Smad3 ablation induces an increase in MAO-mediated DA catabolism in the ST. (A) Loss of Smad3 leads to increased catabolism of striatal DA, with no alterations in total neurotransmitter content. (B) The catabolism of DA in Smad3 deficient mice is primarily MAO-mediated (DOPAC/DA ratio) as compared to COMT (3-MT/DA). (C) The striatal GSH content of Smad3 -/- mice is also higher than in Smad3 +/+ mice. (*P < 0.05, **P < 0.01, ***P < 0.001, Student's t-test, n = 6 per genotype)
