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. 2011 Nov 17;6(11):e27879. doi: 10.1371/journal.pone.0027879

Figure 4. Defective islet development in Ran transgenic mice.

Figure 4

A, Pancreas tissues from non-TG, Ran-WT, Ran-G19V or Ran-T24N transgenic mice were analyzed by H&E or immunohistochemical staining with an antibody to insulin. B, Pancreas sections from non-TG, asymptomatic Ran-WT or diabetic Ran-WT transgenic mice were analyzed for islet number or islet surface area by morphometry of insulin-stained areas. Islet number, non-TG (n = 2), 29.5±1.5; Ran-WT (n = 3), 23±1.73, n.s., not significant; Ran-WT diabetic (n = 3), 9.33±0.88, **, p = 0.001; islet surface area, non-TG (n = 2), 0.51±0.02; Ran-WT (n = 3), 0.35±0.021, *, p = 0.017; Ran-WT diabetic (n = 3), 0.057±0.004, **, p<0.0001. C, Pancreas tissues from Ran-WT, Ran-G19V or Ran-T24N transgenic mice were analyzed by immunohistochemical staining with antibodies to somatostatin or glucagon.