Figure 6. Defective islet cell proliferation in Ran transgenic mice.
A, Pancreas section from non-TG or Ran-WT transgenic mice were harvested at the indicated postnatal (P) age and analyzed for Ki-67 reactivity, by immunohistochemistry. Sections from normal mouse spleen were used as control. B, The number of Ki-67+ cells/islet surface area (0.02 mm2) was quantified by morphometry. **, p = 0.0081. C, Pancreas section from non-TG or Ran-WT transgenic mice (P50) were analyzed for TUNEL reactivity and the numbers of positive cells was quantified. Mean±SD.