Fig. 1.

Based on the cumulative concentration-effect curves for rocuronium on a ST at 0.1 Hz (A) and TF at 50 Hz for 1.9 seconds (B), clindamycin shifted curves to the left; thus, clindamycin augments the potency of rocuronium. Twelve preparations were studied. Rocuronium concentrations are presented as means ± SD and where a single experiment was performed (n = 1, no SD). CM: clindamycin. ^*Indicates P < 0.0009, EC₅₀ of rocuronium in 0.5 mM clindamycin compared to no clindamycin.