Fig. 2.

Based on the cumulative concentration-effect curves for rocuronium on a ST at 0.1 Hz (A) and TF at 50 Hz for 1.9 seconds (B), clindamycin shifted curves to the left; hence, clindamycin augments the potency of rocuronium in the presence of neostigmine. Clindamycin at 1.0 mM shifted the concentration-response curve of rocuronium in the presence of neostigmine to the rocuronium alone curve. Rocuronium concentrations are presented as means ± SD except where a single experiment was performed (n = 1, no SD). CM: clindamycin, R alone: rocuronium in the absence of both clindamycin and neostigmine. ^*Indicates P < 0.05, EC₅₀ of rocuronium with 0.5 mM clindamycin and ^†Indicates P < 0.005, EC₅₀ of rocuronium with 1.0 mM clindamycin compared to no clindamycin.