Table 1.
Methods for Carcinogen Administration in the Trout Tumor Model
| Compound | Exposure Route | Target Organs | References |
|---|---|---|---|
| Dibenzo[a,l]pyrene (DBP) | Diet | ST, LV, SB | (Bailey et al., 2009; Bailey et al., 1996; Reddy al., 1999 1999a; b; Pratt et al., 2007) |
| Microinjection, embryo | LV | ||
| Benzo[a]pyrene (BaP) | Diet | LV | (Hendricks et al., 1985; Bailey et al., 1996) |
| i.p. injection | LV | ||
| Microinjection, embryo | LV | ||
| 7,12-Dimethylbenz[a]anthracene (DMBA) | Diet | ST, LV | (Fong et al., 1993; Bailey et al., 1996) |
| Water, embryo | LV, ST, K | ||
| Water, fry | ST, LV, SB, K | ||
| Microinjection, embryo | LV, ST | ||
| (±)-trans-B[a]P-7,8-dihydrodiol | Microinjection, sac-fry | LV | (Kelly et al., 1993a; Bailey et al., 1996) |
| Microinjection, embryo | |||
| (+)-11,12-DBP-dihydrodiol | Microinjection, embryo | LV | (Kelly et al., 1993a; 1993b) |
| (−)-11,12-DBP-dihydrodiol | Microinjection, embryo | LV | (Kelly et al., 1993a; 1993b) |
| (+)-syn-11,12-DBP-dihydrodiol epoxide | Microinjection, embryo | LV | (Kelly et al., 1993a; 1993b) |
| (−)-anti-11,12 DBP-dihydrodiol epoxide | Microinjection, embryo | LV | (Kelly et al., 1993a; 1993b) |
a
ST= stomach; LV= liver; K= kidney, SB= swim bladder.