Fig. (2).

Schematic diagram of involvement of DNA methylation in different cellular processes. DNA methylation is the best known epigenetics alteration in prostate cancer. DNA methylation can regulate gene expression and can function in favor of malignancy-associated phenotypes such as cellular differentiation, growth, migration and invasion, metastasis, apoptosis, hormonal regulation of steroid receptors, and DNA repair. DNA methylation appears to be very sensitive to external stimuli or influences such as diet and oxidative stress.