Table 2.
Genes Frequently Hypomethylated in Prostate Cancer
| Gene | Chra | Role/Function | Hypo methylation | Prostate cancer | Cell linesd | Ref. # | |
|---|---|---|---|---|---|---|---|
| Primaryb | Metsc | ||||||
| Urokinase Plasminogen Activator (uPA) | 10q24 | Tumor invasion and metastasis | 75-96.9% | + | + | [220] | |
| Heparanase (HPSE) | 4q21 | Tumor invasion and metastasis | 8.5 -30% | + | + | [142] | |
| Cancer/testis Antigen Gene (CAGE) | 6p24 | Cell cycle control: cellular proliferation | 34% | + | [151] | ||
| Cytochrome P4501B1(CYP1B1) | 2p21 | Hydroxylation of estrogens and activation of carcinogens | 5 17% | + | + | [143] | |
a
Chr: Chromosomal location.
b
Primary prostate cancers.
c
Mets: Metastatic prostate cancer.
d
Prostate cancer cell lines.