Fig. (1) Major gene expression changes in ALS.

Schematic representation of the most important findings from studies performed on human ALS and their related mutant SOD1 transgenic models. Upper lines represent disease progression in patients, and lower lines represent disease progression in animals. Gene functional categories are indicated for different tissues or cells. The inset shows the progression of the cellular events and clinical symptoms corresponding to each pathological stage in the mouse (pre-symptomatic, early symptomatic and late symptomatic). N/A, not available; surv., survival; comm., communication.