Table 2.

Frequencies of alterations (gain, amplification and loss) in low/intermediate-grade and high-grade DCIS and adjacent IDC present in 39 breast tumor samples

	DCIS		IDC
	Low/intermediate grade	High-grade	Low/intermediate grade	High-grade
ESR1	16	15	13	25
EGFR	5	10	0	4
FGFR1	32	55	27	38
ADAM9	58	45	67	50
IKBKB	37	40	47	38
PRDM14	11	40	33	29
MTDH	53	65	47	83
MYC	42	65	47	63
CCND1	53	40	27	42
EMSY	11	20	33	33
CDH1	21	15	7	25
TRAF4	42	65	33	58
CPD	21	40	53	33
MED1	42	50	40	29
HER2	21	65	33	33
CDC6	42	55	47	42
TOP2A	47	45	47	29
MAPT	16	35	7	21
BIRC5	26	30	13	13
CCNE1	0	15	7	4
AURKA	0	25	7	8

DCIS ductal carcinoma in situ, IDC invasive ductal carinoma