Table 2.
Down regulation of LTBP4 in malignant tissues
| Group | p-value | Fold change | ||
|---|---|---|---|---|
| Microarray | Murine DCIS and IDC compared to non-malignant control | 2 m | 1.7E-02 | 2.1 ↓ |
| 3 m | 4.1E-03 | 2.1 ↓ | ||
| 4 m | 5.0E-03 | 2.0 ↓ | ||
| 5 m | 3.5E-03 | 2.5 ↓ | ||
| IDC | 9.5E-04 | 11.7 ↓ | ||
| Human DCIS and IDC compared to non-malignant control | DCIS | 1.8E-02 | 5.9 ↓ | |
| IDC | 1.5E-02 | 8.9 ↓ | ||
| qPCR | Murine DCIS and IDC compared to non-malignant control | 2 m | 5.5E-03 | 2.1 ↓ |
| 3 m | 4.9E-03 | 2.2 ↓ | ||
| 4 m | 1.7E-02 | 1.6 ↓ | ||
| 5 m | 3.5E-03 | 2.4 ↓ | ||
| IDC | 5.6E-04 | 13.4 ↓ | ||
| Human DCIS and IDC compared to non-malignant control | DCIS | 1.3E-02 | 5.7 ↓ | |
| IDC | 1.0E-02 | 9.0 ↓ | ||
p-values and Fold Changes of LTBP4 in murine and human DCIS and IDC. p-values and fold Changes of LTBP4 in murine and human DCIS and IDC compared to non-malignant control samples (2 m = 2 month after lactation, 3 m = 3 month after lactation, 4 m = 4 month after lactation, 5 m = 5 month after lactation, IDC = invasive ductal carcinoma). Fold Changes were calculated using the median of the non-malignant controls compared to the different time points or the invasive tumors. Malignant and premalignant tissues were down regulated compared to non-malignant controls. Microarray and quantivative real time PCR values are shown